Nucleic acid monoclonal antibodies targeting PCSK9 and methods of use
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsDavid Weiner, Makan Khoshnejad, Kar Muthumani, Ami Patel
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Abstract
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.
Claims14
A composition for generating one or more anti-PCSK9 antibodies or antigen-binding fragments thereof in a subject, comprising one or more nucleic acid molecules encoding one or more anti-PCSK9 antibodies or antigen-binding fragments thereof;
- wherein the composition comprises:
- a) a nucleotide sequence encoding an amino acid sequence having at least about 99% identity over the entire length of at least one amino acid sequence selected from the group of SEQ ID NOs:
- 1, 3, 5 and 7, wherein the encoded CDRs comprises 100% identity to the CDRs of SEQ ID NO:
- 1, 3, 5 or 7;
- b) a nucleotide sequence having at least about 99% identity over the entire length of at least one nucleotide sequence selected from the group of SEQ ID NOs:
- 2, 4, 6 and 8, wherein the nucleotide sequences encoding the CDRs comprises 100% identity to the CDR coding sequences of SEQ ID NO:2, 4, 6 and 8;
- or c) any combination thereof.
Dependencies are inferred from the claim text.