ICOS ligand variant immunomodulatory proteins and uses thereof
AssigneeAlpine Immune Sciences, Inc.
InventorsRyan Swanson, Michael Kornacker
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Abstract
Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
Claims21
A variant ICOS Ligand (ICOSL) polypeptide, comprising one or more amino acid substitutions at one or more positions in an unmodified ICOSL corresponding to position(s) selected from the group consisting of 54, 84, 119, 120, 143, 152, 155, 203, and 207 with reference to the numbering of residues in SEQ ID NO:32, wherein the unmodified ICOSL comprises (i) the sequence of amino acids set forth in SEQ ID NO:32, or (ii) a portion of the sequence of (i) comprising an IgV domain, wherein the IgV domain is amino acids 19-129 of SEQ ID NO:5.
Dependencies are inferred from the claim text.