Anti-BTLA antibody
AssigneesShanghai Junshi Biosciences Co., Ltd., Junmeng Biosciences Co., Ltd.
InventorsHai Wu, Jian Yao, Sheng Yao, Hui Feng, Jing Zhang, Yuehua Zhou
Life of this patent
Estimating the term…
Loading patent…
AssigneesShanghai Junshi Biosciences Co., Ltd., Junmeng Biosciences Co., Ltd.
InventorsHai Wu, Jian Yao, Sheng Yao, Hui Feng, Jing Zhang, Yuehua Zhou
Estimating the term…
The present invention relates to an anti-BTLA antibody or an antigen-binding fragment thereof comprising: at least one light chain CDR domain selected from SEQ ID NOs: 7, 8, 9, 10, 11, 12, 16, 17, 18, 22, 23, 24, 31, 32 and 33, and/or at least one heavy chain CDR domain selected from SEQ ID NOs: 1, 2, 3, 4, 5, 6, 13, 14, 15, 19, 20, 21, 25, 26, 27, 28, 29 and 30. The present invention also relates to a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, a corresponding expression vector and a host cell, as well as therapeutic use of the antibody or the antigen-binding fragment thereof, the nucleic acid molecule, the expression vector and the host cell.
An isolated anti-BTLA antibody or an antigen-binding fragment thereof wherein the amino acid sequences of the LCDR1, LCDR2 and LCDR3 of the light chain CDR and the amino acid sequences of the HCDR1, HCDR2 and HCDR3 of the heavy chain CDR of the isolated antibody or the antigen-binding fragment thereof are selected from any one of the following groups I-IX:
Dependencies are inferred from the claim text.