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US 12,110,327 B2Granted
Anti-TREM1 antibodies and methods of use thereof
AssigneeAlector LLC
InventorsAndrew Pincetic, Arnon Rosenthal, Helen Lam, Francesca Avogadri-Connors, Seung-Joo Lee
Life of this patent
Estimating the term…
Abstract
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM1 protein, e.g., a mammalian TREM1 or human TREM1, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
Claims22
An isolated antibody that binds to a TREM1 protein, comprising a heavy chain and a light chain, wherein the light chain comprises a hypervariable region L1 (HVR-L1) comprising the amino acid sequence of SEQ ID NO:
- 10, an HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 29, and an HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 101, and wherein the heavy chain comprises an HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 130, an HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 159, and an HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 229.
3 more elements
Dependencies are inferred from the claim text.