Single domain antibodies for complement regulation

A single domain antibody capable of specifically binding to an epitope of a human and/or mouse C1q complement factor, wherein the single domain antibody comprises a complementarity determining region-1 (CDR1), a complementarity determining region-2 (CDR2), and a complementarity determining region-3 (CDR3);

• wherein:
• (a) the CDR1 comprises the amino acid sequence of SEQ ID NO:
• 10, the CDR2 comprises the amino acid sequence of SEQ ID NO:
• 11, and the CDR3 comprises the amino acid sequence of SEQ ID NO:
• 12;
• (b) the CDR1 comprises the amino acid sequence of SEQ ID NO:
• 14, the CDR2 comprises the amino acid sequence of SEQ ID NO:
• 15, and the CDR3 comprises the amino acid sequence of SEQ ID NO:
• 16;
• (c) the CDR1 comprises the amino acid sequence of SEQ ID NO:
• 18, the CDR2 comprises the amino acid sequence of SEQ ID NO:
• 19, and the CDR3 comprises the amino acid sequence of SEQ ID NO:
• 20;
• (d) the CDR1 comprises the amino acid sequence of SEQ ID NO:
• 22, the CDR2 comprises the amino acid sequence of SEQ ID NO:
• 23, and the CDR3 comprises the amino acid sequence of SEQ ID NO:
• 24;
• (e) the CDR1 comprises the amino acid sequence of SEQ ID NO:
• 26, the CDR2 comprises the amino acid sequence of SEQ ID NO:
• 27, and the CDR3 comprises the amino acid sequence of SEQ ID NO:
• 28;
• (f) the CDR1 comprises the amino acid sequence of SEQ ID NO:
• 30, the CDR2 comprises the amino acid sequence of SEQ ID NO:
• 31, and the CDR3 comprises the amino acid sequence of SEQ ID NO:
• 32;
• (g) the CDR1 comprises the amino acid sequence of SEQ ID NO:
• 34, the CDR2 comprises the amino acid sequence of SEQ ID NO:
• 35, and the CDR3 comprises the amino acid sequence of SEQ ID NO:
• 36;
• or
• (h) the CDR1 comprises the amino acid sequence of SEQ ID NO:
• 38, the CDR2 comprises the amino acid sequence of SEQ ID NO:
• 39, and the CDR3 comprises the amino acid sequence of SEQ ID NO:
• 40.