Cleavable activators of CXCR3 and methods of use
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorAlan H. Wells
Life of this patent
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Abstract
Recombinant C-X-C motif chemokine ligand (CXCL) peptides modified to introduce a cleavage site for a protease, such as a protease activated during an inflammatory response, are described. The CXCL peptides have the capacity to activate CXCR3 until being cleaved by the protease. Proteolytic cleavage of the CXCL peptide minimizes the pro-inflammatory response and inhibits the development of fibrosis.
Claims9
A recombinant C-X-C motif chemokine ligand (CXCL) peptide, comprising a modification relative to a wild-type CXCL amino acid sequence, wherein the modification is a cleavage site for a protease and wherein the amino acid sequence of the peptide comprises SEQ ID NO:
- 2.
A recombinant C-X-C motif chemokine ligand (CXCL) peptide, comprising a modification relative to a wild-type CXCL amino acid sequence, wherein the modification is a cleavage site for a protease, and wherein the amino acid sequence of the peptide consists of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.