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US 12,110,292 B2Granted
Ligands to cereblon (CRBN)
AssigneeDana-Farber Cancer Institute, Inc.
InventorsNathanael Gray, Tinghu Zhang, Eric Fischer, Zhixiang He, Guangyan Du, Katherine Donovan, Radoslaw Nowak, Jing Ting Christine Yuan
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds with immunomodulatory activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysfunctional protein activity.
Claims16
A compound of Formula (Ia1) or Formula (Ib1):
- wherein:
- Z represents CH2;
- R2 is H or C1-C2 alkyl;
- and
- R3 is optionally substituted C1-C5 alkyl, optionally substituted C6-C14 aryl, optionally substituted C6-C14 heteroaryl, optionally substituted C5-C14 carbocyclic or optionally substituted C5-C14 heterocyclic, or R2 and R3 together with the N to which they are bound form an optionally substituted C6-C14 heterocyclic group or an optionally substituted C6-C14 heteroaryl group;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
3 more elements
A compound which is selected from the group consisting of:
- or a pharmaceutically acceptable salt or stereoisomer thereof.
Dependencies are inferred from the claim text.