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US 12,110,291 B2Granted
Glutarimide-containing pan-KRAS-mutant degrader compounds and uses thereof
AssigneeTiger Biotherapeutics Inc.
InventorsRobert Luo, Ji Liu, Pin Huang, Jie Su, Yan Feng, Ke Liu, Jie Fan, Wei He, Yimin Qian
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Abstract
The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.
Claims32
A compound, wherein the compound is represented by Formula IB′ or is a pharmaceutically acceptable salt thereof:
- wherein:
- each Rb is independently selected from halogen, hydroxy, amino, and C1-C4 alkyl;
- n′ is 1 or 2;
- R2 is H;
- R3 is halogen;
- Q is selected from
- and
- L is selected from
5 more elements
Dependencies are inferred from the claim text.