Heterocyclic derivatives as Nav1.7 and Nav1.8 blockers

A compound of the following formula (I):

• wherein:
• A is phenyl, pyridyl, or quinolyl;
• R1 is selected from the group consisting of:
• C1-6 alkyl, —O—C1-6 alkyl, and fluorobenzyloxy;
• wherein the C1-6 alkyl or the —O—C1-6 alkyl, is substituted with one or more fluorines;
• R2 is independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) hydroxyl, (4) C1-6 alkyl, (5) —OC1-6 alkyl, and (6) —CN;
• wherein the C1-6 alkyl or the —O—C1-6 alkyl is unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
• halogen and hydroxyl;
• P is 0, 1, 2, 3, or 4;
• when p is two or more, each R2 is the same or different;
• R1 and R2 may substitute anywhere on the A ring;
• n is 1, 2, or 3;
• Z is CH, CR3, or N;
• R3 is independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) hydroxyl, (4) C1-6 alkyl, and (5) —O—C1-6 alkyl;
• q is 0, 1, 2, or 3;
• when q is two or more, each R3 is the same or different;
• R4 is selected from the group consisting of:
• (1) C1-6 alkyl and (2) C3-7 cycloalkyl, wherein the C1-6 alkyl or the C3-7 cycloalkyl is unsubstituted or substituted with one or more substituents independently selected form the group consisting of:
• halogen, hydroxyl, C1-6 alkyl, —O—C1-6 alkyl, and C3-7 cycloalkyl;
• R5a and R5b are independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) hydroxyl, and (4) C1-6 alkyl, which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
• halogen and hydroxyl;
• R5a and R5b may substitute anywhere on the carbon atoms of the heterocyclic ring;
• when R5a and R5b substitute at the same position, R5a may form a 3 to 6 membered cycloalkyl ring with R5b;
• and
• R5c, is (1) hydrogen or (2) C1-6 alkyl;
• or a pharmaceutically acceptable salt thereof.