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US 12,110,271 B2Granted
Manufacturing method for 4-methoxypyrrole derivatives
AssigneeDaewoong Pharmaceutical Co., Ltd.
InventorsJeong-Taek Shin, Jeong-Hyun Son, Deok Ki Eom
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Abstract
The present disclosure relates to a manufacturing method for 4-methoxypyrrole derivatives. The embodiment of the present disclosure is useful for industrial mass production of 4-methoxypyrrole derivatives, because the process efficiency and yield are improved, and the use of hazardous reagents and environmental polluting reagents is avoided.
Claims22
A method for manufacturing 4-methoxypyrrole derivatives, comprising:
- 1) a step of preparing a compound represented by the following Chemical Formula 4 by reacting a compound represented by the following Chemical Formula 2 with a compound represented by the following Chemical Formula 3;
- 2) a step of preparing a compound represented by the following Chemical Formula 5 by reacting a compound represented by the following Chemical Formula 4 with sodium borohydride;
- 3) a step of preparing a compound represented by the following Chemical Formula 6 by reacting a compound represented by the following Chemical Formula 5 with an oxidant;
- and
- 4) a step of reacting a compound represented by the following Chemical Formula 6 with methylamine to produce an intermediate, and converting the intermediate to a compound represented by the following Chemical Formula 1 by adding a reductant:
2 more elements
Dependencies are inferred from the claim text.