Test cartridge for analysis instruments
AssigneeIllumina Singapore Pte. Ltd.
InventorsBeng Keong Ang, Shyun Long Wang, Heng Kuang Cheng, Chow Jin Chng, Ai Wee Lee, Yashwanth Panduga
Life of this patent
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Abstract
A test cartridge for insertion into an analysis instrument having an actuation mechanism, the test cartridge having one or more sensors for measuring an aspect of the actuation mechanism.
Claims33
A test cartridge for insertion into an analysis instrument having a linear actuation mechanism, a rotational actuation mechanism, a heater, a pump actuation mechanism, a second linear actuation mechanism, and a cartridge receiver, the test cartridge comprising:
- a test cartridge housing having a form factor configured to be received by the cartridge receiver of the analysis instrument;
- a plurality of first linear translation sensors, each first linear translation sensor having a corresponding first detector and a corresponding first movable element linearly translatable along a corresponding first axis, wherein at least a first portion of each of the first linear translation sensors is positioned within the test cartridge housing such that the corresponding first movable element thereof is configured to engage with the linear actuation mechanism of the analysis instrument when the test cartridge is inserted into the analysis instrument and the linear actuation mechanism of the analysis instrument is actuated, and wherein the first detector of each of the first linear translation sensors is configured to detect a first distance moved by the corresponding first movable element along the corresponding first axis relative to the test cartridge housing and responsive to a linear input provided by the linear actuation mechanism of the analysis instrument when the test cartridge is inserted into the analysis instrument and the linear actuation mechanism of the analysis instrument is actuated;
- a second linear translation sensor having a second detector and a second movable element linearly translatable along a second axis, wherein at least a second portion of the second linear translation sensor is positioned within the test cartridge housing such that the second movable element is configured to engage with the pump actuation mechanism of the analysis instrument when the test cartridge is inserted into the analysis instrument and the pump actuation mechanism of the analysis instrument is actuated, and wherein the second detector is configured to detect a second distance moved by the second movable element along the second axis relative to the test cartridge housing when the test cartridge is inserted into the analysis instrument and the pump actuation mechanism of the analysis instrument is actuated;
- an angular rotation sensor having a third detector and a rotatable element rotatable about a third axis, wherein the angular rotation sensor is positioned within the test cartridge housing such that the rotatable element is configured to engage with the rotational actuation mechanism of the analysis instrument when the test cartridge is inserted into the analysis instrument and the rotational actuation mechanism of the analysis instrument is actuated, and wherein the third detector is configured to detect an angle moved by the rotatable element about the third axis relative to the test cartridge housing when the test cartridge is inserted into the analysis instrument and the rotational actuation mechanism of the analysis instrument is actuated;
- a temperature sensor having a receptacle in the test cartridge housing and a temperature detector positioned within the receptacle, wherein the temperature sensor is positioned within the test cartridge housing such that the receptacle is configured to engage with the heater of the analysis instrument when the test cartridge is inserted into the analysis instrument, and wherein the temperature detector is configured to detect a temperature inside the receptacle when the test cartridge is inserted into the analysis instrument;
- and
- a plurality of load cells, wherein each of the load cells is positioned within the test cartridge housing such that each load cell is configured to engage with the second linear actuation mechanism of the analysis instrument when the test cartridge is inserted into the analysis instrument and the second linear actuation mechanism of the analysis instrument is actuated, and wherein each of the load cells is configured to detect a force applied to the respective load cell when the test cartridge is inserted into the analysis instrument and the second linear actuation mechanism of the analysis instrument is actuated.
A test cartridge for insertion into an analysis instrument having a linear actuation mechanism and a cartridge receiver, the test cartridge comprising:
- a test cartridge housing having a form factor configured to be received by the cartridge receiver of the analysis instrument;
- and
- a plurality of linear translation sensors, each of the linear translation sensors having a corresponding first detector and a corresponding first movable element linearly translatable along a corresponding first axis, wherein at least a portion of each of the linear translation sensors is positioned within the test cartridge housing of the test cartridge such that the corresponding first movable element thereof is configured to engage with the linear actuation mechanism of the analysis instrument when the test cartridge is inserted into the analysis instrument and the linear actuation mechanism of the analysis instrument is actuated, and each first detector is configured to detect a distance moved by the corresponding first movable element along the corresponding first axis relative to the test cartridge housing when the test cartridge is inserted into the analysis instrument and the linear actuation mechanism of the analysis instrument is actuated.
A test cartridge for insertion into an analysis instrument having a rotational actuation mechanism, a heater, and a cartridge receiver, the test cartridge comprising:
- a test cartridge housing having a form factor configured to be received by the cartridge receiver of the analysis instrument and a port configured to receive the heater of the analysis instrument;
- a first angular rotation sensor having a first detector and a first rotatable element rotatable about a first rotation axis, wherein the first angular rotation sensor is positioned within the test cartridge housing such that the first rotatable element is configured to engage with the rotational actuation mechanism of the analysis instrument when the test cartridge is inserted into the analysis instrument and the rotational actuation mechanism of the analysis instrument is actuated, and wherein the first detector is configured to detect a first angle moved by the first rotatable element about the first rotation axis relative to the test cartridge housing when the test cartridge is inserted into the analysis instrument and the rotational actuation mechanism of the analysis instrument is actuated;
- and
- a temperature sensor having a receptacle in the test cartridge housing and a temperature detector positioned within the receptacle, wherein the temperature sensor is positioned within the test cartridge housing such that the receptacle is configured to engage with the heater of the analysis instrument when the test cartridge is inserted into the analysis instrument, wherein the receptacle is configured to be heated by the heater of the analysis instrument, and wherein the temperature detector is configured to detect a temperature inside the receptacle.
A test cartridge for insertion into an analysis instrument having a pump actuation mechanism and a cartridge receiver, the test cartridge comprising:
- a test cartridge housing having a form factor configured to be received by the cartridge receiver of the analysis instrument, wherein the test cartridge includes a first hole and a second hole opposite the first hole, and the second hole is configured to receive a portion of the pump actuation mechanism of the analysis instrument;
- and
- a linear translation sensor having a detector and a movable element linearly translatable along a first axis, wherein:
- at least a portion of the movable element is positioned within the test cartridge housing of the test cartridge,
- the movable element is positioned in between the first hole and the second hole,
- the movable element is configured to engage with and is movable by the portion of the pump actuation mechanism received by the second hole when the test cartridge is inserted into the analysis instrument and the pump actuation mechanism of the analysis instrument is actuated,
- the movable element is configured to be movable through the first hole when the test cartridge is inserted into the analysis instrument and the pump actuation mechanism of the analysis instrument is actuated to move the movable element, and
- the detector is configured to detect a distance moved by the movable element along the first axis relative to the test cartridge housing.
Dependencies are inferred from the claim text.