A method of establishing a fluid flow path in a drug delivery device including a reservoir having a sidewall defining an interior for containing a drug and a first end, a needle fixed within the first end of the reservoir with a first end extending forwardly from the reservoir and a second end fluidly connected to the interior of the reservoir, and a needle shield valve member having a body defining an inlet coupled to the reservoir, an outlet, and a barrier extending between the inlet and the outlet to prevent fluid flow through the body, wherein the needle is prevented from moving relative to the neck, the method comprising:
- coupling the reservoir to the inlet of the body in a first position so that a tip of the needle is embedded within or spaced from the barrier;
- moving at least one of the reservoir and the needle shield valve member to a second position so that the tip of the needle extends through the barrier to establish a fluid flow path from the interior of the reservoir to the outlet of the body.