Electrospun fibrous matrix, its preparation method and uses thereof

A method of producing an electrospun fibrous matrix, comprising:

• (a) mixing a first polymer and a drug to form a first mixture;
• (b) sonicating the first mixture of the step (a) until a plurality of microparticles are formed with the drug being encapsulated therein;
• (c) mixing the plurality of microparticles of the step (b) with a second polymer to form a second mixture;
• (d) subjecting the second mixture of the step (c) to an electrospinning process in a solution to produce a plurality of first and second fibrils, wherein each of the second fibrils has the plurality of microparticles independently integrated and disposed along the longitudinal direction of the second fibrils, while each of the first fibrils is devoid of the microparticles;
• and
• (e) weaving the plurality of first and second fibrils to form the electrospun fibrous matrix,
• wherein the first polymer and the second polymer are different wherein the first polymer is poly(lactic-co-glycolic acid) (PLGA) and the second polymer is poly(vinyl alcohol) (PVA).