Hydrocortisone acetate suppository formulation for treatment of disease
AssigneeCristcot LLC
InventorsJennifer J. Davagian, Raj Devarajan
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Abstract
The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
Claims17
A method of treating a gastrointestinal disease selected from ulcerative colitis or Crohn's disease, comprising rectally administering to a subject in need thereof a formulation comprising about 0.5% to about 5% by weight hydrocortisone acetate, about 0.1% to about 5% by weight colloidal silicon dioxide, a semi-synthetic glyceride base comprising saturated C8-C18 triglyceride fatty acids, and lecithin, wherein the formulation has a melting temperature in the range of about 37° C. to about 39° C.
Dependencies are inferred from the claim text.