US 12,109,303 B2 · Orally dissolving antimicrobial film compositions and methods of their use

Abstract

Disclosed herein are ionic liquid composition(s) of amphotericin B comprising amphotericin B; a complexing agent component; a solvent component comprising acidified solvent(s); and a solubilizing component. Disclosed composition(s) comprise at least two complexing agents and two or more constituents of the composition provide two or more functional activities. Ionic liquid composition(s) disclosed are in aspects provided as oral dissolve film(s) useful in the treatment of oral microbial infection(s), e.g., oral candidiasis. Disclosed ionic liquid composition(s) of amphotericin B and ODF(s) thereof have a solubility of amphotericin B in water of at least 3 mg/mL. ODF film(s) provided deliver a localized concentration of amphotericin B to the oral cavity of a recipient wherein the concentration of amphotericin B available for treating a source of a local infection is detectably or significantly greater than that provided by an orally delivered, intravenously delivered, or either orally or intravenously delivered treatment comprising amphotericin B.

Claims20

Dependent claims

An antifungal ionic liquid composition of amphotericin B comprising (1) amphotericin B;

(2) a complexing agent component comprising a first complexing agent and a second complexing agent, wherein the first complexing agent and the second complexing agent form a single ionic complex with the amphotericin B;
(3) a solvent component comprising an amount of at least one solvent compound and at least one solvent acidifying agent that when combined with the solvent compound forms an acidified solvent, wherein the at least one solvent acidifying agent further (a) represents one of the first or the second complexing agents forming the ionic complex with the amphotericin B and (b) detectably modulates the pH of the composition;
and (4) a solubilizing component comprising an amount of at least one solubilizing agent which detectably or significantly increases the solubilization of the amphotericin B, wherein each of the solvent acidifying agent and the solvent compound are present in the composition in an amount representing between about 0.5% w/v and about 5% w/v of the composition.

Dependencies are inferred from the claim text.

Orally dissolving antimicrobial film compositions and methods of their use

Life of this patent

Orally dissolving antimicrobial film compositions and methods of their use

Life of this patent

Abstract

Claims20