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US 12,109,301 B2Granted
Formulations, methods, and systems for treating genitourinary conditions
AssigneesMassachusetts Institute of Technology, The General Hospital Corporation
InventorsXiang Li, Michael J. Cima, Brian H. Eisner
Life of this patent
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Abstract
Provided are formulations and methods for treating one or more genitourinary conditions. The formulations may include a therapeutic agent that includes a calcium channel blocker, a rho kinase inhibitor, or a combination thereof. The methods may include locally administering a therapeutic agent into a ureter. Systems for delivering a therapeutic agent also are provided.
Claims15
A formulation for local administration to a ureter of a patient, the formulation comprising:
- a therapeutic agent selected from a calcium channel blocker, a rho kinase inhibitor, or a combination thereof;
- and
- one or more pharmaceutically acceptable excipients,
- wherein the formulation is suitable for local administration into the ureter, the formulation is configured to delay passage of the formulation from the ureter, and the formulation is in the form of a liquid solution or a viscous vehicle.
1 more element
A drug delivery system comprising:
- a delivery device, comprising at least a part thereof which is configured for insertion into a ureter of a patient;
- and
- a formulation comprising a therapeutic agent selected from a calcium channel blocker, a rho kinase inhibitor, or a combination thereof, and wherein the formulation is in the form of a liquid solution or a viscous vehicle,
- wherein the delivery device is configured to deliver the therapeutic agent to the ureter in an amount effective to relax human ureteral smooth muscle in vivo.
1 more element
Dependencies are inferred from the claim text.