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US 12,109,274 B2Granted
Polynucleotides containing a stabilizing tail region
AssigneeModernaTX, Inc.
InventorsGabor Butora, Andrew W. Fraley, Edward John Miracco, Jennifer Nelson, Amy Rhoden Smith, Matthew Stanton, Brian R. Fritz
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Abstract
The invention features polynucleotides encoding a polypeptide including a 3′-stabilizing region and having increased stability compared to wild-type polynucleotides.
Claims9
A polynucleotide encoding a polypeptide, wherein said polynucleotide comprises:
- (a) a 5′-cap structure;
- (b) a 5′-UTR;
- (c) a coding region encoding the polypeptide;
- (d) a 3′-UTR;
- and
- (e) a 3′-stabilizing region comprising 1 to 500 nucleosides, wherein one or more of said nucleosides is an inverted thymidine.
3 more elements
Dependencies are inferred from the claim text.