Motile sperm domain containing protein 2 and inflammation
AssigneeImmuneWalk Therapeutics, Inc.
InventorsItzhak Mendel, Oshrat Propheta-Meiran, Yaniv Salem, Anat Shoham, Eyal Breitbart
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Abstract
Disclosed herein are methods of treating, preventing, or reducing the incidence of an inflammatory disease or disorder and methods of inhibiting, preventing, or reducing the incidence of one or more activities in a cell with an inhibitor of a Motile Sperm Domain containing Protein 2 (MOSPD2). Also disclosed are inhibitors of MOSPD2 and pharmaceutical compositions containing MOSPD2 inhibitors.
Claims20
A method of treating a chronic inflammatory disease or disorder in a subject, comprising administering to the subject an inhibitor of MOSPD2, wherein the inhibitor is an RNA silencing agent, and
- wherein the chronic inflammatory disease or disorder is rheumatoid arthritis, systemic lupus erythematosus, scleroderma, mixed connective tissue disease, polyarteritis nodosa, polymyositis/dermatomyositis, Sjogren's syndrome, Behcet's disease, multiple sclerosis, autoimmune diabetes, Hashimoto's disease, psoriasis, primary myxedema, pernicious anemia, myasthenia gravis, chronic active hepatitis, autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, uveitis, vasculitides, or heparin induced thrombocytopenia.
Dependencies are inferred from the claim text.