Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients

A low nitrogen protein food composition for a patient in need thereof comprising as active ingredients amounts of at least five alpha keto analogues of an amino acid:

• a) wherein the amounts of the alpha keto analogues are:
• i) a magnesium salt of leucine at about 28.37% wt./wt., methionine at about 8.18% wt./wt., and valine at about 6.06% wt./wt.;
• ii) a calcium salt of isoleucine at about 15.0% wt./wt., phenylalanine at about 1.31% wt./wt., and valine at about 10.09% wt./wt.;
• b) wherein the low nitrogen protein food composition comprises up to 500 mg daily of nitrogen
• c) wherein the patient has Stage 4 kidney disease, is not on dialysis, and experiences a slowdown in the progression of said Stage 4 kidney disease;
• and
• d) wherein the patient experiences on average:
• a 42% reduction in blood urea nitrogen;
• a 23% reduction in creatinine;
• a 28% increase in glomerular filtration rate (GFR);
• and a lower tacrolimus dose for transplant patients.

A low nitrogen protein food composition for a patient in need thereof comprising as active ingredients amounts of at least five alpha keto analogues of an amino acid:

• a) wherein the amounts of the alpha keto analogues are a calcium salt of:
• isoleucine at about 14.77% wt./wt., leucine at about 28.67% wt./wt., methionine at about 8.09% wt./wt., phenylalanine at about 1.30% wt./wt., and valine at about 16.00% wt./wt.;
• b) wherein the low nitrogen protein food composition comprises up to 500 mg daily of nitrogen
• c) wherein the patient has Stage 5 kidney disease, is not on dialysis, and experiences a slowdown in the progression of said Stage 5 kidney disease;
• and iv) wherein said treatment program slows the progression of incurable chronic kidney disease;
• and
• d) wherein the patient experiences on average:
• a 42% reduction in blood urea nitrogen;
• a 23% reduction in creatinine;
• a 28% increase in glomerular filtration rate (GFR);
• and a lower tacrolimus dose for transplant patients.