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US 12,109,249 B2Granted
Compositions and methods for treating inflammation and cancer
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsNejat Egilmez, Neal Bhutiani
Life of this patent
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Abstract
Compositions and methods for the treatment of cancer and/or inflammatory diseases are provided. A combination of interleukin-10 (IL-10) and interleukin-12 (IL-12) is used to treat cancer and/or inflammatory diseases, and a combination of an anti-PD-1 antibody and an anti-IL-17 antibody is used to treat cancer.
Claims7
A method of treating a cancer in a subject in need thereof, comprising
- treating the subject with an anti-PD-1 antibody,
- measuring a level of IL-17 produced by CD4+ T-cells in the subject,
- identifying an increase in IL-17 produced by CD4+ T-cells, and
- administering to the subject a combination of an anti-IL-17 antibody and an anti-PD-1 antibody,
- wherein the cancer is colon cancer or lung cancer.
2 more elements
Dependencies are inferred from the claim text.