Pharmaceutical preparation and medical device

A method for preventing or treating rhinitis in a subject in need thereof, the method comprising administering a composite particle to an intranasal mucosa of the subject,

• wherein the composite particle comprises at least one titanium oxide particle, at least one metal particle and at least one calcium phosphate particle,
• wherein the at least one metal particle is at least one metal particle selected from the group consisting of a silver particle, a gold particle, a platinum particle and a copper particle,
• wherein administering the composite particle to the intranasal mucosa of the subject comprises inserting a medical device into a nasal cavity of the subject,
• wherein the medical device comprises a sheet portion inserted into the nasal cavity of the subject and the composite particle attached to the sheet portion, and
• wherein the medical device is inserted into the nasal cavity of the subject so that the composite particle attached to the sheet portion comes into contact with the intranasal mucosa of the subject, and so that a part of the medical device is inserted into the nasal cavity of the subject and the other part remains outside of the nasal cavity of the subject.