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US 12,109,232 B2Granted
Radiation/chemotherapy sensitizer to be used for intratumoral local injection and for controlled release of hydrogen peroxide with hydrogel as carrier
AssigneeKORTUC Inc.
InventorsYasuhiro Ogawa, Shiho Tokuhiro, Hideki Oda, Norikazu Yokota, Ryo Akima
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Abstract
The present invention provides a radiation sensitizer or anti-cancer chemotherapy sensitizer that prevents the decomposition of hydrogen peroxide for a longer period of time, and that maintains its effect. The radiation sensitizer or anti-cancer chemotherapy sensitizer according to the present invention is characterized by using hydrogen peroxide together with a hydrogel containing a crosslinked gelatin gel.
Claims7
A sensitizer comprising a combination of:
- (a) hydrogen peroxide at a concentration of 0.5 to 3.5 w/v % and (b) a hydrogel comprising a crosslinked gelatin gel prepared from a gelatin having an isoelectric point of 4.5 to 5, wherein the crosslinked gelatin gel is in a particulate form, the hydrogel is at a concentration of 0.5 to 10 w/v %, and the sensitizer is in an intratumoral injection form.
Dependencies are inferred from the claim text.