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US 12,109,215 B2Granted
Combination therapies for inhibition of polo-like kinase 4
AssigneeUniversity Health Network
InventorsJacqueline M. Mason, Mark R. Bray, Tak Wah Mak, Graham Fletcher
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Abstract
Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
Claims8
A method for treating colon cancer, comprising:
- administering to a subject an effective amount of a compound represented by the formula:
- or a pharmaceutically acceptable salt thereof and an effective amount of a PD-1 inhibitor.
A method for treating colon cancer, comprising:
- administering to a subject an effective amount of a compound represented by the formula:
- or a pharmaceutically acceptable salt thereof and an effective amount of durvalumab.
Dependencies are inferred from the claim text.