Formulation and treatment methods
AssigneeProdrugxtend Pty Ltd
InventorsTimothy Florin, Amirali Popat, Siddharth Jambhrunkar
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Abstract
The invention relates to pharmaceutical compositions comprising 6-thioguanine (6-TG) wherein the composition is formulated for release of 6-TG in the distal intestine. Methods for treating a disease or condition of the distal ileum that responds to 6-TG wherein the 6-TG is released in the distal intestine are also disclosed.
Claims20
A method for treating inflammatory bowel disease in an individual in need thereof, the method comprising administering a pharmaceutical composition comprising 6-thioguanine (6-TG) and a homogeneous erodible hydrophilic polymer matrix to the individual, wherein the composition is formulated for oral administration, wherein the composition exhibits an in vitro release of at least 35% of the 6-TG at pH 6 to about pH 7.5 after 12 hours.
A method for treating inflammatory bowel disease in an individual in need thereof, the method comprising administering a pharmaceutical composition comprising 6-thioguanine (6-TG) and a homogeneous erodible hydrophilic polymer matrix, wherein the composition is formulated for oral administration and to release at least 35% of the 6-TG in the distal intestine of the individual.
Dependencies are inferred from the claim text.