Substituted oxazolidinones for the treatment of mammalian infections

A compound of general formula (I),

• or a pharmaceutically acceptable salt thereof, wherein, X is either absent or a bond;
• whenever X is absent, the four membered ring is directly attached to the 6-membered piperidine ring forming spirocyclic system with the spiro carbon at position 4 of the piperidine ring and Q being beta to the spiro carbon;
• Q is either O or S(O)p;
• p=0-2 integer;
• Y is OH, NR2R3, or NHC(O)R4;
• R1 is selected from H, F, Cl, CH3, CN and OCH3;
• m=1-4 integer;
• R2 and R3 are independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl, aryl, heterocyclyl and heteroaryl each of which may be further optionally substituted;
• or Rz and R3 are taken together with the nitrogen to which they are attached to form a 4- to 8-membered heterocyclyl or heteroaryl with 1 to 3 additional heteroatoms selected from O, S, or N, which heterocyclyl or heteroaryl may be further be optionally substituted;
• R4 is independently selected from (C1-C6)alkyl, (C3-C6)cycloalkyl, aryl, heteroaryl and (C1-C6)alkoxy, each of which is optionally substituted;
• substitutions are selected from halo, hydroxyl, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)acyloxy, haloalkyl, NO2, CN and NH2.