Methods and compositions for treatment of epileptic disorders
AssigneeOvid Therapeutics Inc.
InventorMatthew During
Life of this patent
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Abstract
Use of allosteric modulators and/or gaboxadol for the treatment of epileptic disorders in a subject in need thereof.
Claims21
A method of treating status epilepticus comprising administering to a human patient diagnosed with status epilepticus an effective amount of ganaxolone,
- wherein the effective amount of ganaxolone is administered by a combination of a first intravenous dose and a second dose continuous infusion, and
- wherein the effective amount provides a consistent ganaxolone plasma concentration of about 500 ng/ml and provides improvement of at least one symptom of the human patient for at least 8 hours after administration.
A method of treating status epilepticus comprising administering to a human patient diagnosed with status epilepticus an effective amount of ganaxolone,
- wherein the effective amount of ganaxolone is administered by a combination of a first intravenous injection and a second dose continuous infusion, and
- wherein the effective amount provides a consistent ganaxolone plasma concentration of at least about 500 ng hr/ml and provides improvement of at least one symptom of the human patient for 8 hours to 12 hours after administration.
A method of treating status epilepticus comprising administering to a human patient diagnosed with status epilepticus a pharmaceutical composition comprising ganaxolone or a pharmaceutically acceptable salt thereof wherein the pharmaceutical composition is administered intravenously to provide about 500 mg to 1000 mg/day ganaxolone and improves at least one symptom for more than 12 hours after administration of the pharmaceutical composition to the patient.
Dependencies are inferred from the claim text.