Materials and methods for inhibiting tumor growth
AssigneesAmiLyfe, LLC, University of Florida Research Foundation, Inc.
InventorsSadasivan Vidyasagar, Reshu Gupta, Stephen Gatto
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Abstract
The subject invention provides compositions and methods for inhibiting the growth and/or proliferation of cancer cells. The subject invention also provides methods for treating cancer in a subject in need of such treatment by administering a composition described herein. The subject invention can be used to inhibit cancer cell growth by exposing the cells to a composition. The subject invention further provides cancer treatments that may be used in combination with surgery, chemotherapy, and/or radiation therapy.
Claims12
A formulation for inhibiting proliferation of cancer cells comprising:
- a therapeutically effective amount of free amino acids, the free amino acids consisting essentially of or consisting of free amino acids of:
- proline, serine, threonine, tyrosine, and valine;
- or
- proline, serine, threonine, tyrosine, valine, asparagine, and glycine;
- and
- optionally a pharmaceutically acceptable carrier, buffer, electrolyte, adjuvant, or excipient;
- wherein a therapeutically effective amount of the formulation inhibits proliferation of cancer cells.
A method of treating cancer expressing anoctamin (ANO) in a subject in need thereof, the method comprising administering to the subject in need thereof a therapeutically effective amount of a formulation comprising:
- a therapeutically effective amount of free amino acids, the free amino acids consisting essentially of or consisting of free amino acids of:
- proline serine, threonine, tyrosine, and valine;
- or
- proline, serine, threonine, tyrosine, valine, asparagine, and glycine;
- and
- optionally a pharmaceutically acceptable carrier, buffer, electrolyte, adjuvant, or excipient;
- wherein the cancer expressing ANO comprises cancer cells and a therapeutically effective amount of the formulation inhibits proliferation of the cancer cells.
A method of inhibiting cancer cell proliferation comprising exposing cancer cells expressing anoctamin (ANO) to a formulation comprising:
- an effective amount of free amino acids, the free amino acids consisting essentially of or consisting of free amino acids of:
- proline, serine, threonine, tyrosine, and valine;
- or
- proline, serine, threonine, tyrosine, valine, asparagine, and glycine;
- and
- optionally a pharmaceutically acceptable carrier, buffer, electrolyte, adjuvant, or excipient;
- wherein the effective amount of the free amino acids inhibits proliferation of the cancer cells expressing ANO.
Dependencies are inferred from the claim text.