Antimicrobial compositions and related methods
AssigneesWest Liberty University, The University of Mississippi
InventorsJoseph A. Horzempa, Elliot M. Collins, Juan Francisco Leon
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Abstract
A pharmaceutical composition is provided that comprises an effective amount of dillapiole or a derivative thereof, and a pharmaceutically-acceptable vehicle, carrier, or excipient. Methods of treating a bacterial infection are also described and include administering an effective amount of dillapiole or a derivative thereof to a subject in need of such treatment. Methods of reducing bacterial virulence are further described and include contacting a bacterium, such as a F. tularensis or A. baumannii bacterium, with an effective amount of dillapiole or a derivative thereof.
Claims11
A method for treating a bacterial infection, comprising administering to a subject in need thereof an effective amount of dillapiole, wherein the bacterial infection is a F. tularensis or an A. baumannii infection, and wherein the dillapiole or the derivative thereof has the formula:
- wherein R1 and R2 are independently selected from a hydrogen atom and an alkyl group;
- or
- wherein R1 is selected from a propene group, a propyne group, a propane group, an isopropyl group, or a cyclopropyl group.
A method for reducing bacterial virulence, comprising contacting a bacterium with an effective amount of dillapiole, wherein the bacterium is a bacterium reliant on activity of MglA/SspA for pathogenesis, and wherein contacting the bacterium with the dillapiole comprises contacting the bacterium with an amount of the dillapiole sufficient to reduce an amount of activity of MglA/SspA in the bacterium or to reduce an expression level of one or more genes controlled by MglA/SspA in the bacterium, and wherein the dillapiole has the formula:
- wherein R1 and R2 are independently selected from a hydrogen atom and an alkyl group;
- or
- wherein R1 is selected from a propene group, a propyne group, a propane group, an isopropyl group, or a cyclopropyl group.
Dependencies are inferred from the claim text.