Personalized methods of treating cancer
AssigneesFaeth Therapeutics, Inc., Cancer Research Technology Limited
InventorOliver D.K. Maddocks
Life of this patent
Estimating the term…
Abstract
Disclosed herein are dietary compositions that are substantially devoid of at least cysteine or a salt thereof for use in treating a cancer. The dietary compositions and methods of the disclosure can be used to treat cancers that are MTAP-deficient, alone or in combination with a cancer therapy.
Claims19
A method for treating a cancer having dysregulated polyamine metabolism in a subject in need thereof, wherein the cancer having dysregulated polyamine metabolism is breast cancer, colorectal cancer, pancreatic cancer, or brain cancer, the method comprising administering to the subject a therapeutically effective amount of a dietary product, wherein:
- the dietary product comprises at most about 0.5% (w/w) of cysteine or cystine;
- the dietary product comprises at least about 7.5% (w/w) of methionine;
- the therapeutically effective amount of the dietary product is from about 0.5 g/kg/day to about 1 g/kg/day;
- and
- the subject is undergoing a cancer therapy for the cancer having dysregulated polyamine metabolism.
Dependencies are inferred from the claim text.