System with guides and tools of different flexibility

A system comprising:

• an actuator couplable to a flexible guide tube and configured to move at least a portion of the flexible guide tube;
• a processor;
• and
• memory storing computer-executable instructions that, when executed by the processor, cause the system to:
• identify at least one factor associated with insertion or removal of a tool configured to be inserted through or removed from the flexible guide tube;
• identify, in a first configuration of the flexible guide tube and based on the at least one factor, one or more sections of the flexible guide tube having one or more bends that the tool cannot traverse, wherein a distal portion of the flexible guide tube is disposed adjacent a target site in the first configuration;
• inform a user that the first configuration includes the one or more sections of the flexible guide tube having the one or more bends that the tool cannot traverse;
• and
• command the actuator to move the flexible guide tube to a second configuration, wherein the second configuration does not include the one or more bends that the tool cannot traverse.