Reverse transcriptases and uses thereof

A nucleic acid comprising a polynucleotide encoding a hybrid reverse transcriptase, the hybrid reverse transcriptase comprising a finger domain, a palm domain, a thumb domain, a connection domain and an RNase H domain, wherein

• (A) the hybrid reverse transcriptase comprises:
• (i) a portion of feline leukemia virus reverse transcriptase (FLVRT) comprising the finger domain and the palm domain, wherein the portion of the FLVRT is at least 95% identical to SEQ ID NO:26, said portion of the FLVRT linked to a portion of mouse leukemia virus reverse transcriptase (MLVRT) comprising the thumb domain, the connection domain, and the RNase H domain, wherein the portion of the MLVRT is at least 95% identical to SEQ ID NO:28;
• or
• (ii) a portion of feline leukemia virus reverse transcriptase (FLVRT) comprising the finger domain, the palm domain, the thumb domain, and the connection domain wherein the portion of the FLVRT is at least 95% identical to SEQ ID NO:27, said portion of the FLVRT linked to a portion of mouse leukemia virus reverse transcriptase (MLVRT) comprising the RNase H domain, wherein the portion of the MLVRT is at least 95% identical to SEQ ID NO:29;
• or
• (B) the hybrid reverse transcriptase comprises:
• a portion of mouse leukemia virus reverse transcriptase (MLVRT) comprising the finger domain and the palm domain, wherein the portion of the MLVRT is at least 95% identical to SEQ ID NO:1, said portion of the MLVRT linked to
• a portion of feline leukemia virus reverse transcriptase (FLVRT) comprising the thumb domain, the connection domain, and the RNase H domain, wherein the portion of the FLVRT is at least 95% identical to SEQ ID NO:5.