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US 12,014,835 B2Granted
Methods for evaluating therapeutic benefit of combination therapies
AssigneesVanderbilt University, Duet BioSystems Inc.
InventorsChristian T. Meyer, Vito Quaranta, Leonard A. Harris, Buddhi Bishal Paudel, David J. Wooten, Laurent Audoly
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Abstract
The invention provides methods for evaluating the therapeutic benefit of a combination therapy useful for treating a medical disorder, such as cancer.
Claims20
A method for evaluating the therapeutic benefit of a combination therapy comprising a first therapeutic agent and a second therapeutic agent to be used in combination to treat a medical disorder, the method comprising the steps of:
- (a) determining, with an electronic processor, a difference in efficacy towards the medical disorder between (i) the combination and (ii) the most efficacious single therapeutic agent in the combination;
- (b) determining, with the electronic processor, a difference in potency towards the medical disorder for the first therapeutic agent between when (i) the first therapeutic agent is used alone and (ii) the first therapeutic agent is used in combination with the second therapeutic agent;
- (c) determining, with the electronic processor, a difference in potency towards the medical disorder for the second therapeutic agent between when (i) the second therapeutic agent is used alone and (ii) the second therapeutic agent is used in combination with the first therapeutic agent;
- (d) selecting the combination, the first therapeutic agent, or the second therapeutic agent, to prescribe for a patient, based on the determining steps of (a), (b), and (c);
- and
- optionally, administering the selected one of the combination, the first therapeutic agent, or the second therapeutic agent to the patient.
3 more elements
Dependencies are inferred from the claim text.