Offline mode in a mobile-native clinical trial operations service suite

A system, comprising:

• one or more computational elements;
• and
• a non-transitory storage medium including instructions executable by the one or more computational elements to configure the one or more computational elements to:
• provide a user interface and network interface modules;
• provide user enrollment, user notification, user secure communication, user engagement, and user data capture service modules;
• provide a trial design service configured to design, create, establish, deploy, or any combination thereof, a trial protocol and a participant interaction procedure using a flowable-based workflow palette in conjunction with visual programming, the flowable-based workflow palette including workflow attributes selectively indicating offline-capable procedures for a user interface for a clinical portal-supporting application configured to collect sensor data from one or more health monitoring sensors as available offline using an offline portal proxy and data caches, allowing the clinical portal-supporting application to continue operating when offline from a server running a clinical trial operations service suite;
• provide, using the workflow attributes, workflows and screens from a service cache from among the data caches as needed for execution by the offline portal proxy while offline;
• and
• provide a synchronization capability, including synchronizing, for a plurality of the offline-capable procedures, the sensor data from an operational data offline cache from among the data caches between the offline portal proxy and the clinical trial operations service suite, resolving data conflicts during the synchronization by sending a notification to a coordinator with appropriate privileges to resolve a conflict, and subsequently flushing the sensor data from the operational data offline cache in response to an acknowledgement when online with the server, wherein synchronization for the plurality of the offline-capable procedures is responsive to an invocation of a synchronization procedure by one of the offline-capable procedures.

A method of operating a trial operations service suite in a clinical trial operations system, comprising:

• producing a trial protocol and a participant interaction procedure using a flowable-based workflow palette in conjunction with visual programming, the flowable-based workflow palette including workflow attributes selectively indicating offline-capable procedures for a user interface for a clinical portal-supporting application as available offline;
• running trial operations service suite software on a computer, the trial operations service suite software incorporating the trial protocol and the participant interaction procedure;
• communicating with a user application running on a user device;
• displaying, based on the workflow attributes and using workflows and screens from a service cache in the computer as needed while the clinical portal-supporting application is offline, at least one of a service screen or the user interface on the user device, the user interface querying for user input for use in a clinical trial;
• receiving the user input on the user device;
• synchronizing when online with the computer, service suite information, service screen logic, sensor data received from one or more health monitoring sensors and stored in an operational data offline cache of the user device, and information from the user input including the information from a plurality of offline-capable procedures for a user interface for the clinical portal-supporting application that are available offline by using the service cache, collected by the user application when the user application is offline from the computer, wherein synchronization for the plurality of the offline-capable procedures is responsive to an invocation of a synchronization procedure by one of the offline-capable procedures;
• resolving data conflicts during the synchronization by sending a notification to a coordinator with appropriate privileges to resolve a conflict;
• sending an acknowledgement of the sensor data from the computer to the user device;
• and
• flushing, in response to the acknowledgement, the sensor data from the operational data offline cache.

A method of operating an application in a clinical trial operations system, comprising:

• producing a trial protocol and a participant interaction procedure using a flowable-based workflow palette in conjunction with visual programming, the flowable-based workflow palette including workflow attributes selectively indicating offline-capable procedures for a user interface for the application as available offline;
• when the application is connected to a portal of a trial operations service suite, synchronizing, for a plurality of the offline-capable procedures, portal and application data, service screens and logic, and offline data collected by the application while not connected based on the workflow attributes selectively indicating the offline-capable procedures for the user interface for the application as available offline, wherein synchronization for the plurality of the offline-capable procedures is responsive to an invocation of a synchronization procedure by one of the offline-capable procedures;
• resolving data conflicts during the synchronization by sending a notification to a coordinator with appropriate privileges to resolve a conflict;
• and
• when the application is not connected to the portal, using a proxy embedded in the application to continue providing service and collecting the offline data according to previously synchronized portal data, service screens, and service logic, based on the workflow attributes selectively indicating the offline-capable procedures for the user interface for the application as available offline from a service cache, wherein the offline data includes sensor data from health monitoring sensors stored in an operational data offline cache while the application is available offline;
• wherein the synchronizing of the portal and application data includes sending an acknowledgement of the sensor data from the portal of the trial operations service suite to the application and flushing, in response to the acknowledgement, the sensor data from the operational data offline cache.