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US 12,007,397 B2Granted
Enhanced detection and quantitation of biomolecules
AssigneePrognomIQ, Inc.
InventorsBruce Wilcox, Kavya Swaminathan, Preston B. Williams, Jared Deyarmin, Mi Yang
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Abstract
Described herein are methods for screening for a disease state. The method may include obtaining multiple data sets, and identifying the disease state based on a combination of the data sets. The data sets may include biomolecule measurements obtained by multiple methods, such as through the use of particles and reference biomolecules.
Claims24
A method for measuring endogenous biomolecules in a biological sample, comprising:
- (a) contacting a first aliquot of the biological sample with nanoparticles, thereby forming biomolecule coronas comprising the endogenous biomolecules of the biological sample adsorbed directly to the nanoparticles;
- (b) measuring the contacted sample of (a) to obtain a first set of measurements;
- (c) contacting a second aliquot of the biological sample with a plurality of reference biomolecules;
- (d) measuring the contacted sample of (c) to obtain a second set of measurements;
- and
- (e) combining the first and second sets of measurements, wherein the plurality of reference biomolecules comprises an isotopic label, a mass tag, a barcode, a post-translation modification, or a biomolecule from a species different than a species of a subject from whom the biological sample was taken.
3 more elements
Dependencies are inferred from the claim text.