Respiratory simulation system including an anatomical model of the human nasal cavity configured for in vitro inhalation studies and associated methods

An anatomical model of a nasal cavity, the model comprising:

• (a) a model body constructed of non-living material, the model body including upper and lower model portions configured to be affixed together to define the nasal cavity and including fluidic channels therein that define an olfactory region of the upper model portion and define a nasal passage of the lower model portion;
• and
• (b) a biocompatible porous membrane positioned between the upper and lower model portions when the upper and lower model portions are affixed together, the biocompatible porous membrane disposed adjacent the fluidic channels that define the olfactory region, wherein the membrane is configured for
• (i) culturing olfactory epithelium cells thereon and
• (ii) receiving particles that flow into the nasal cavity of the model body toward the fluidic channels that define the olfactory region;
• wherein the upper and lower model portions are configured to be separated and spaced from one another to enable access to the biocompatible membrane between the upper and lower model portions.