Compensation voltage adjustment for ion mobility separation
AssigneeThermo Finnigan LLC
InventorsBennett S. Kalafut, Dhruva D. Kulkarni, Satendra Prasad, Michael W. Belford
Life of this patent
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Abstract
Adjusting compensation voltage (CV) parameters of an ion mobility device is described. In one instance, the CV parameters are adjusted to reflect a different CV range, a number of CV steps, or a CV step size to increase throughput of a mass spectrometer.
Claims22
A mass spectrometry system comprising:
- an ionization source configured to receive a sample and form ions from the sample;
- a field asymmetric-waveform ion-mobility spectrometry (FAIMS) device configured to receive the ions;
- and
- a controller configured to acquire peak information related to transmission of the ions through the FAIMS device based on initial compensation voltage (CV) parameters used for the FAIMS device, and the controller configured to adjust the initial CV parameters based on the peak information to generate adjusted CV parameters used by the FAIMS device, the adjusted CV parameters being one or more of:
- a CV range different than the initial CV parameters, a number of CV steps within the CV range different than the initial CV parameters, or a CV step size between CV values of the CV range different than the initial CV parameters, and wherein the adjusted CV parameters includes more steps within the CV range than the initial CV parameters.
A method of operating a mass spectrometer comprising:
- acquiring, by a processor, peak information indicative of transmissions of ions through an ion mobility device using first compensation voltage (CV) parameters;
- determining, by the processor, second CV parameters based on the peak information, the second CV parameters being different from the first CV parameters by one or more of:
- a CV range, a number of CV steps within the CV range, or a CV step size between CV values of the CV range, and wherein the number of CV steps within the CV range of the second CV parameters is more than the number of CV steps of the first CV parameters;
- applying the second CV parameters to the ion mobility device;
- and
- acquiring mass spectra using the ion mobility device applied with the second CV parameters.
A mass spectrometry system comprising:
- an ion mobility device configured to transmit ions;
- and
- a controller circuit configured to acquire transmission information indicative of the ions transmitting through the ion mobility device based on use of first compensation voltage (CV) parameters, configured to generate second CV parameters different than the first CV parameters, and configured to use the second CV parameters to facilitate the transmission of the ions through the ion mobility device, the second CV parameters being different than the first CV parameters by one or more of:
- a CV range, a number of CV steps within the CV range, or a CV step size among CV values used within the CV range, wherein the number of CV steps of the second CV parameters is hither than the number of CV steps for the first CV parameters.
A computer program product including one or more non-transitory computer-readable media having computer programs instructed stored therein, the computer program instructions being configured such that, when executed by one or more computing devices, the computer program instructions cause the one or more computing devices to:
- acquire peak information indicative of transmissions of ions through an ion mobility device using first compensation voltage (CV) parameters;
- determine second CV parameters based on the peak information, the second CV parameters being different from the first CV parameters by one or more of:
- a CV range, a number of CV steps within the CV range, or a CV step size between CV values of the CV range, wherein the number of CV steps of the second CV parameters is higher than the number of CV steps for the first CV parameters;
- apply the second CV parameters to the ion mobility device;
- and
- acquire mass spectra using the ion mobility device applied with the second CV parameters.
Dependencies are inferred from the claim text.