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US 12,007,320 B2Granted
Assay detection, accuracy and reliability improvement
AssigneeEssenlix Corporation
InventorsStephen Y. Chou, Wu Chou, Xing Li, Hongbing Li, Yuecheng Zhang, Mingquan Wu, Wei Ding, Jun Tian
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Abstract
The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.
Claims19
A system for improving the accuracy of an assay device that detects an analyte in a sample, wherein the sample, the assay device, or an operation of the assay device has one or more imperfect conditions, the system comprising:
- (a) an assay device that detects, under the one or more imperfect conditions, the analyte in the sample to generate a detection result, wherein the assay device has a sample holder that holds the sample;
- (b) an imager that images the sample in the sample holder to obtain images;
- (c) a non-transitory storage medium that stores an algorithm that analyzes the image(s) and a reliability of the detection result to generate a trustworthiness of the detection results, wherein the trustworthiness is higher when the analysis of the reliability shows that the detection result has a lesser likelihood of being inaccurate, and wherein the algorithm comprises at least a machine learning algorithm, a statistical model, a lookup table, or any combination of;
- (d) a processor that executes the algorithm to determine the trustworthiness of the detection result;
- and
- (e) a data-output device that outputs the detection result, if the trustworthiness is higher than a predetermined trustworthiness threshold;
- otherwise not reporting the detection result.
4 more elements
Dependencies are inferred from the claim text.