Methylome based analysis and treatment for meningioma
AssigneeUniversity Health Network
InventorsGelareh Zadeh, Kenneth Aldape, Farshad Nassiri, Yasheng Maimaitijiang
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AssigneeUniversity Health Network
InventorsGelareh Zadeh, Kenneth Aldape, Farshad Nassiri, Yasheng Maimaitijiang
Estimating the term…
There is described herein a method of predicting recurrence free survival in a patient with meningioma comprising: (a) determining a tumor DNA methylation profile from a tumor sample from the patient, the tumor DNA methylation profile comprising the methylation status of at least 200 loci represented by the probes set forth in Table 9; and (b) calculating a risk of meningioma recurrence based on comparing the tumor DNA methylation profile and a reference methylation profile comprising the extent to which the methylation status of the at least 200 loci is associated with a risk of recurrence.
An array consisting of probes for detecting CpG methylation at all 2332 loci represented by the following 2332 probes:
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