Methods utilizing leukocyte RNA expression in prognosis evaluation of medical interventions for epilepsy

A method of treating a subject with intractable epilepsy, comprising the steps of:

• a) obtaining RNA from leukocytes from the subject;
• b) based on the RNA present in the leukocytes, determining an expression level of 24 genes consisting of:
• FAM155A, ABCA4, ZFP57, IFI27, C5orf17, PLP1, PVRL2, FAM118A, GFAP, CDYL, CPEB4, FADS2, RSAD2, BIN3, BRSK1, AKAP7, IL22RA1, BGN, MMP8, PF4VI, MDGA1, ALOX15B, HBG1, and B4GALNT3;
• c) comparing the determined expression level with a control expression level for each gene;
• d) detecting upregulation of FAM155A, ABCA4, ZFP57, IFI27, C5orf17, PLP1, PVRL2, FAM118A, GFAP, CDYL, CPEB4, FADS2, RSAD2, BIN3, BRSK1, and AKAP7, and detecting downregulation of IL22RA1, BGN, MMP8, PF4VI, MDGA1, ALOX15B, HBG1, and B4GALNT3 relative to the control expression level for each gene;
• and
• e) treating the subject with ablation treatment.