Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids

A method wherein an artificial intelligence (AI) enabled automated flow synthesis platform, the method comprising:

• receiving one or more measurements from one or more detectors, wherein the one or more measurements comprise a spectral profile at each coupling of each amino acid in the sequence, and the one or more detectors are monitoring a synthesis of the sequence in a reaction chamber;
• determining, using one or more trained machine learning models, a synthesizing recipe that enables the sequence to be synthesized, wherein the synthesizing recipe comprises one or more parameters used to control at least the reaction chamber during an automated flow process to synthesize the sequence;
• and
• controlling, using the synthesizing recipe, the synthesis of the sequence in the reaction chamber.

A system for an automated flow synthesis platform configured to use an artificial intelligence (AI) engine and comprising:

• a reaction chamber configured to synthesize a sequence;
• one or more detectors configured to monitor the synthesis of the sequence in the reaction chamber, wherein the synthesis uses an automated flow process;
• and
• a computing device communicatively coupled to the one or more detectors, wherein the computing device is configured to:
• receive one or more measurements from the one or more detectors, wherein the one or more measurements comprise a spectral profile at each coupling of each amino acid in the sequence;
• determine, using one or more trained machine learning models, a synthesizing recipe that enables the sequence to be synthesized, wherein the synthesizing recipe comprises one or more parameters used to control at least the reaction chamber during the automated flow process to synthesize the sequence;
• and
• control, using the synthesizing recipe, the synthesis of the sequence in the reaction chamber.