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US 12,006,530 B2Granted
Streptococcal proteases
AssigneeGenovis AB
InventorsUlrich Von Pawel-Rammingen, Christian Spoerry
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Abstract
The invention relates to new Streptococcal proteases designated IgdE which display IgG degrading cysteine protease activity. The invention further relates to in vitro methods of cleaving IgG using the described Streptococcal proteases, using the methods to generate Fc and Fab fragments, and using the methods to detect IgG.
Claims9
An in vitro method for the cleavage of human IgG1, the method comprising contacting human IgG1 with a purified polypeptide in vitro, wherein the purified polypeptide comprises:
- (a) the amino acid sequence of SEQ ID NO:
- 3;
- (b) a variant thereof having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 3 and having human IgG1 cysteine protease activity;
- or
- (c) a fragment thereof of either (a) or (b), having human IgG1 cysteine protease activity.
3 more elements
Dependencies are inferred from the claim text.