Fusion proteins and methods thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsAntonio Iavarone, Anna Lasorella
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Abstract
The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.
Claims24
A method for treating a FGFR3-TACC3 fusion associated cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of JNJ-42756493, wherein the subject has a FGFR3-TACC3 fusion associated cancer, wherein the FGFR3-TACC3 fusion comprises a tyrosine kinase domain of FGFR3 fused to the TACC domain of transforming acidic coiled-coil-containing (TACC)3.
A method for diagnosing and treating a FGFR3-TACC3 fusion associated cancer in a subject in need thereof, the method comprising:
- a. obtaining a biological sample from the subject;
- b. detecting whether the subject has a FGFR3-TACC3 fusion is present in the biological sample, wherein the FGFR3-TACC3 fusion comprises a tyrosine kinase domain of FGFR3 fused to the TACC domain of transforming acidic coiled-coil-containing (TACC) 3;
- and
- c. diagnosing the subject with a FGFR3-TACC3 fusion associated cancer when the presence of the FGFR3-TACC3 fusion in the biological sample is detected;
- then
- d. administering to the subject an effective amount of JNJ-42756493.
Dependencies are inferred from the claim text.