Composition of drug targets and method of using thereof

A drug combination comprising siRNAs that target human or mouse FK506 binding protein 10 (FKBP10) and siRNAs that target human or mouse procollagen C-endopeptidase enhancer (PCOLCE) transcript,

• wherein sequence of the siRNA for human FKBP10 mRNA are as follows:
• sense strand:
• SEQ ID NO:
• 1, 5′-GAAGGAAGAUUAUCAUCCCUCCAUU-3′;
• antisense strand:
• SEQ ID NO:
• 2, 5′-AAUGGAGGGAUGAUAAUCUUCCUUC-3′;
• wherein sequence of the siRNA for mouse FKBP10 mRNA are as follows:
• sense strand:
• SEQ ID NO:
• 3, 5′-CCACACCUACAAUACCUAUTT-3′;
• antisense strand:
• SEQ ID NO:
• 4, 5′-AUAGGUAUUGUAGGUGUGGTT-3′;
• wherein sequence of the siRNA for human PCOLCE mRNA are as follows:
• sense strand:
• SEQ ID NO:
• 5, 5′-CCUUCCUCCAGAGAGCUUU-3′;
• antisense strand:
• SEQ ID NO:
• 6, 5′-AAAGCUCUCUGGAGGAAGG-3′;
• wherein sequence of the siRNA for mouse PCOLCE mRNA are as follows:
• sense strand:
• SEQ ID NO:
• 7, 5′-CCUGGCAACCAAGUGACUU-3′;
• antisense strand:
• SEQ ID NO:
• 8, 5′-AAGUCACUUGGUUGCCAGG-3′.