Humanized anti-MUC1* antibodies

A polypeptide comprising an anti-MUC1* antibody fragment, wherein the anti-MUC1* antibody fragment comprises a heavy chain variable region and a light chain variable region that have complementarity determining regions (CDRs) in the heavy chain variable region and the light chain variable region as follows:

• CDR1 heavy chain SEQ ID NO:
• 123,
• CDR1 light chain SEQ ID NO:
• 173,
• CDR2 heavy chain SEQ ID NO:
• 127,
• CDR2 light chain SEQ ID NO:
• 177,
• CDR3 heavy chain SEQ ID NO:
• 131, and
• CDR3 light chain SEQ ID NO:
• 181;
• wherein the heavy chain variable region comprises an amino acid sequence that has at least 90% sequence identity to SEQ ID NO:
• 145 and the light chain variable region comprises an amino acid sequence that has at least 90% sequence identity to SEQ ID NO:
• 195;
• and
• wherein the polypeptide binds to a receptor on an immune cell.