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US 12,006,367 B2Granted
CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
AssigneeIchnos Sciences SA
InventorsRomain Ollier, Samuel Hou, Rami Lissilaa, Darko Skegro, Jonathan Back
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Abstract
The present invention relates to hetero-dimeric immunoglobulins that target both a component of the human CD3 antigen and a component of the human CD38 antigen and methods of making the same. The present invention also relates to antibodies which bind to the human CD38 antigen and derivatives thereof for use as therapeutic or diagnostic reagents and methods of making the same.
Claims9
An antibody or fragment thereof that binds to human CD38 comprising a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:
- 25 or SEQ ID NO:
- 208, and a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:
- 26 or SEQ ID NO:
- 209, and a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:
- 27 or SEQ ID NO:
- 210;
- and comprising a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:
- 28 or SEQ ID NO:
- 211 or SEQ ID NO:
- 214, and a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:
- 29 or SEQ ID NO:
- 212, and a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:
- 30 or SEQ ID NO:
- 213.
11 more elements
Dependencies are inferred from the claim text.