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US 12,006,359 B2Granted
Methods for altering body composition by administering anti-pro/latent myostatin antibodies
AssigneeScholar Rock, Inc.
InventorsAdriana Donovan, Michelle Straub, Stefan Wawersik
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Abstract
The present invention relates to antibodies that specifically bind pro-myostatin and/or latent myostatin, and methods and uses thereof.
Claims8
A method for improving body composition in a subject in need thereof, the method comprising administering to the subject a pro/latent myostatin inhibitor in an amount effective to alter body composition, wherein the pro/latent myostatin inhibitor is an antibody or antigen-binding fragment thereof comprising:
- (a) a heavy chain amino acid sequence that is at least 95% identical to SEQ ID NO:
- 50 and a light chain amino acid sequence that is at least 95% identical to SEQ ID NO:
- 51;
- (b) a heavy chain variable region sequence that is at least 95% identical to SEQ ID NO:
- 73 and a light chain variable region sequence that is at least 95% identical to SEQ ID NO:
- 74;
- or
- (c) a heavy chain variable region sequence that is at least 95% identical to SEQ ID NO:
- 78 and a light chain variable region sequence that is at least 95% identical to SEQ ID NO:
- 79.
7 more elements
Dependencies are inferred from the claim text.