Transthyretin antibodies and uses thereof
AssigneeMor Research Applications Ltd.
InventorsMichael Fassler, Jacob George
Life of this patent
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Abstract
The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human transthyretin (TTR). The anti-TTR antibodies or antigen-binding fragments thereof are useful, for example, in detecting TTR and in treating TTR amyloidosis in a subject.
Claims16
An antibody or antigen-binding fragment thereof capable of binding human transthyretin (TTR), wherein the antibody or antigen-binding fragment thereof comprises a complementary determining region (CDR) H1 comprising the amino acid sequence of SEQ ID NO:1 (GYTFTSYY), a CDR H2 comprising the amino acid sequence of SEQ ID NO:2 (IYPGNVNT), a CDR H3 comprising the amino acid sequence of SEQ ID NO:3 (ARTYFDY), a CDR L1 comprising the amino acid sequence of SEQ ID NO:4 (SSVSY), a CDR L2 comprising the amino acid sequence of SEQ ID NO:5 (DTS), and a CDR3 L3 comprising the amino acid sequence of SEQ ID NO:6 (QQWSSKSFT).
Dependencies are inferred from the claim text.