Anti-CCT5 binding molecules and chimeric antigen receptors comprising the same

An antibody or antigen-binding fragment thereof that specifically binds to a chaperonin containing TCP1 subunit 5 (CCT5) protein comprising:

• a heavy chain variable (VH) region comprising a heavy chain complementarity determining region 1 (CDR-H1), a CDR-H2, and a CDR-H3, respectively, comprising the amino acid sequences of CDR-H1, CDR-H2, and CDR-H3 sequences contained within the VH region amino acid sequence set forth in SEQ ID NO:
• 1;
• and
• a light chain variable (VL) region comprising a light chain complementarity determining region 1 (CDR-L1), a CDR-L2, and a CDR-L3, respectively, comprising the amino acid sequences of CDR-L1, CDR-L2, and CDR-L3 sequences contained within the light chain variable (VL) region amino acid sequence set forth in SEQ ID NO:
• 2.

An antibody or antigen-binding fragment thereof that specifically binds to a chaperonin containing TCP1 subunit 5 (CCT5) protein, wherein the antibody or antigen-binding fragment comprises:

• a heavy chain variable (VH) region comprising a CDR-H1 comprising the amino acid sequence set forth in SEQ ID NO:11;
• a CDR-H2 comprising the amino acid sequence set forth in SEQ ID NO:
• 12;
• and a CDR-H3 comprising the amino acid sequence set forth in SEQ ID NO:13;
• and
• a light chain variable (VL) region comprising a CDR-L1 comprising the amino acid sequence set forth in SEQ ID NO:21;
• a CDR-L2 comprising the amino acid sequence set forthin SEQ ID NO:
• 22;
• and a CDR-L3 comprising the amino acid sequence set forth in SEQ ID NO:
• 23.