Triblock peptide amphiphiles, micelles and methods of use

A triblock peptide of formula A-B-C, wherein one of A, B, and C is a lipid moiety, one of A, B, and C is a peptide block, and one of A, B, and C is a zwitterion-like block;

• wherein A, B, and C are in an arrangement selected from the group consisting of lipid-peptide-zwitterion, lipid-zwitterion-peptide, peptide-lipid-zwitterion, peptide-zwitterion-lipid, zwitterion-lipid-peptide, and zwitterion-peptide-lipid;
• wherein the lipid moiety is PalmK or Palm2K;
• wherein the peptide block is selected from the group consisting of SEQ ID NO:
• 1, SEQ ID NO:
• 2, SEQ ID NO:
• 3, or SEQ ID NO:
• 4;
• wherein the zwitterion-like block is (EK)4 or (KE)4;
• and
• wherein the triblock peptide assembles into a micelle when in a liquid.

A pharmaceutical composition, the composition comprising a triblock peptide of the formula:

• A-B-C
• wherein
• A is a lipid moiety, wherein the lipid moiety is PalmK or Palm2K;
• and
• B and C are independently a peptide block or a zwitterion-like block, wherein one of B and C is a peptide block and the other of B and C is a zwitterion-like block;
• wherein the peptide block is selected from the group consisting of SEQ ID NO:
• 1, SEQ ID NO:
• 2, SEQ ID NO:
• 3, or SEQ ID NO:
• 4;
• and the zwitterion-like block is (EK)4 or (KE)4;
• and
• a pharmaceutically acceptable carrier, wherein the triblock peptide is arranged in a micelle.