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US 12,006,345 B2Granted
Untargeted and targeted IL-10 Fc-fusion proteins
AssigneeXencor, Inc.
InventorsGregory Moore, Rajat Varma, Yoon Kyung Kim, Rumana Rashid, Alex Nisthal, Juan Diaz, Matthew Bernett, Michael Hedvat
Life of this patent
Estimating the term…
Abstract
The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CD8 and NKG2D.
Claims13
A composition comprising a variant interleukin-10 (IL-10) monomer domain consisting of a parent IL-10 monomer domain with an amino acid substitution or a set of amino acid substitutions,
- wherein the parent IL-10 monomer domain is SEQ ID NO:3 or SEQ ID NO:4;
- wherein the amino acid substitution or the set of amino acid substitutions are selected from the group consisting of:
- N21D, D28N, Q38E, Q42E, D44N, N45D, E142Q, D144N, E151Q, Q38E/D41N, Q38E/Q42E, Q38E/N45D, Q38E/E142Q, Q38E/D144N, D41N/Q42E, D41N/N45D, D41N/E142Q, D41N/D144N, Q42E/N45D, Q42E/E142Q, Q42E/D144N, N45D/E142Q, N45D/D144N, E142Q/D144N, N21D/Q42E, N21D/N45D, N21D/E151Q, N21D/N45E, Q42E/E151Q, N45D/E151Q, N21D/Q42E/N45D, N21D/Q42E/E151Q, Q42E/N45D/E151Q, N21D/Q42E/N45E, and N21D/Q42E/N45D/E151Q of SEQ ID NO:3 or SEQ ID NO:4.
Dependencies are inferred from the claim text.